Serum Human Epididymis Protein 4 (HE4) Concentration
This test measures the concentration of HE4, a protein found in higher levels in certain cancers of the female reproductive system, such as ovarian cancer.
["HE4 helps doctors assess risk and monitor treatment in ovarian cancer and other related conditions."]
Key facts at a glance
- LOINC
- 55180-4
- Short code
- HE4 SerPl-sCnc
- Synonyms
- HE4 SerPl-sCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you have symptoms like abdominal pain, bloating, or irregular menstrual cycles. It may also be used during screening for ovarian cancer, especially in high-risk groups, or to monitor existing cancer treatment effectiveness.
What to Expect Before the Test
No special preparation is usually needed. You may be asked to fast for 8–12 hours before the test, but this depends on your provider’s instructions. Bring any medications you’re currently taking.
What Happens During the Test
A healthcare professional will draw blood from a vein in your arm. The process is quick and typically causes mild discomfort. The blood sample is then sent to a lab for analysis.
What the Results Mean
Results are interpreted by your doctor based on your medical history, symptoms, and other tests. Elevated levels may suggest ovarian cancer or other conditions, but they are not definitive on their own. Your provider will discuss the results with you.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
HE4 Blood Test
Frequently asked questions
HE4 is often used alongside other markers (like CA-125) to improve diagnostic accuracy. It may also help track cancer progression or response to treatment in ovarian cancer patients.
How often should I get this test? Your doctor will determine the frequency based on your health needs, risk factors, and test results.
What if my results are abnormal? If your HE4 level is elevated, your doctor may recommend further testing (like imaging or additional bloodwork) to investigate further.
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy