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C-reactive protein (CRP) with high-sensitivity measurement

Published: August 9, 2026Updated: August 16, 2026

This blood test measures a protein called C-reactive protein, which your body produces in response to inflammation. It helps assess whether inflammation is present in your body.

Quick summary

["hs-CRP helps track inflammation, aiding early detection of conditions like heart disease or infection."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
54063-3
Short code
HEDIS 2009 PPC-C RUBV
Synonyms
HEDIS 2009 PPC-C RUBV
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order hs-CRP to monitor chronic conditions like arthritis, heart disease, or autoimmune disorders. It can also help check for signs of infection or inflammation after surgery or injury.

What to Expect During the Test

A small blood sample is taken from a vein, usually in your arm. You may feel a slight pinch, but it’s quick and painless. No special preparation is needed.

How Results Are Interpreted

Results are compared to general reference ranges for inflammation, though individual values can vary. Higher levels may signal inflammation, while lower levels suggest minimal or no inflammation.

Common Conditions Monitored

hs-CRP is often used alongside other tests to evaluate risks for cardiovascular disease, track inflammatory diseases, or guide treatment decisions for conditions like rheumatoid arthritis.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: hs-CRP plays a key role in identifying and managing inflammation-related health risks. While not a definitive diagnostic tool, it supports broader assessments of your health status and helps tailor treatments to reduce inflammation over time.

Short name

hs-CRP

Frequently asked questions

What does a high hs-CRP level mean?
A high hs-CRP level may indicate inflammation in your body, which can be linked to conditions like infections, autoimmune diseases, or heart disease. Your provider will discuss results in the context of your overall health.
How often should I get this test?
Frequency depends on your medical needs. Your healthcare provider will determine how often to check hs-CRP, often as part of routine monitoring for chronic conditions or after a specific concern is raised.
Can lifestyle changes affect hs-CRP levels?
Yes, lifestyle factors like diet, exercise, and stress management can influence inflammation. Small, positive changes—such as eating anti-inflammatory foods or reducing stress—may help lower hs-CRP levels over time.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy