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Hepatitis D Virus Antibody, Screening (IgM)

Published: August 9, 2026Updated: August 17, 2026

This test checks for antibodies to the Hepatitis D virus, which can indicate past or current infection. Hepatitis D is a rare virus that only infects people who already have Hepatitis B.

Quick summary

["Screening for past Hepatitis D infection helps assess your risk for complications and guide future healthcare decisions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
74245-2
Short code
HEDIS 2014-16 Grp A Strep
Synonyms
HEDIS 2014-16 Grp A Strep
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
10
Ref high
40
Critical range
— – 500 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84484
SNOMED
302774002
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects IgM antibodies specific to Hepatitis D virus. IgM antibodies are typically produced shortly after infection and can indicate an active immune response. This test is used as a screening tool to identify past exposure to the virus.

Why It Matters for You

While Hepatitis D is less common than Hepatitis B or C, it can worsen liver damage if both viruses are present. Detecting past infection helps healthcare providers monitor liver health and recommend appropriate preventive measures.

How the Test Works

This test uses an immunoassay method to detect IgM antibodies in a blood sample. Blood is drawn from a vein in your arm, and the sample is analyzed in a lab to check for the presence of these antibodies.

What to Expect Before the Test

No special preparation is needed for this test. You may have some mild discomfort or bruising at the injection site, but this usually fades quickly. If you’re on blood-thinning medication, let your provider know before the test.

Reference range

Adult: 10-40 U/LN/A

Specimen: serum

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

IgM Hepatitis D Antibody

Frequently asked questions

Why might my doctor order this test?
Your doctor may recommend this test if you have a history of Hepatitis B infection, live in an area with higher rates of Hepatitis D, or have symptoms like fatigue, abdominal pain, or jaundice. It helps rule out or confirm past exposure to the virus.
What does a positive result mean?
A positive result suggests you’ve had Hepatitis D in the past. While it doesn’t indicate active infection, it means your immune system has recognized the virus. Follow-up care with your provider is important to monitor liver health.
Can I get Hepatitis D if I’ve already had Hepatitis B?
Yes, Hepatitis D only infects people who already have Hepatitis B. It can worsen liver damage if both viruses are present, so vaccination against Hepatitis B is the best prevention if you’re at risk.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy