Herpes Simplex Virus Antibody (IgG) – Serology
This blood test detects antibodies to herpes simplex virus (HSV), which helps identify past exposure to the virus responsible for cold sores (oral HSV-1) or genital herpes (genital HSV-2).
["This test can help determine if you’ve been exposed to herpes virus in the past."]
Key facts at a glance
- LOINC
- 74247-8
- Short code
- HEDIS 2014-19 HSV Ab
- Synonyms
- HEDIS 2014-19 HSV Ab
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Does This Test Measure?
The test measures **IgG antibodies** against HSV. IgG antibodies develop after an initial infection and remain in your blood for years, indicating past exposure. This does not distinguish between HSV-1 or HSV-2, but confirms prior infection.
Why Might You Need This Test?
Doctors may order this test if you have symptoms like cold sores, genital sores, or recurrent outbreaks, especially if you’re unsure about your infection history. It can also be used for screening in certain high-risk groups or during pregnancy to assess risk.
What to Expect Before the Test
No special preparation is needed. You’ll have a small needle inserted into your arm to draw blood. The process takes about 5 minutes, and you may feel a brief pinch. If you’re pregnant or have a bleeding disorder, let your provider know before testing.
What to Expect After the Test
After the blood draw, you may experience mild bruising, swelling, or discomfort at the site. Apply gentle pressure and ice if needed. Avoid vigorous activity for a few hours. Results are typically ready within 3–5 business days.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Positive results indicate past HSV infection, meaning you’ve likely been exposed to the virus. This does not mean you’re currently infected or contagious, but it confirms immunity or prior exposure. Negative results suggest no detectable antibodies, meaning either you’ve never been exposed or the test was taken too early after infection. This test is not used to diagnose active herpes outbreaks but can guide further evaluation if needed.
Short name
HSV IgG Antibody
Frequently asked questions
How long does it take to get results?
Can I get herpes from a positive test?
Does this test differentiate between HSV-1 and HSV-2?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy