Hemoglobin S Disease Screening (Qualitative)
This test checks for the presence of hemoglobin S, a variant of hemoglobin that can cause sickle cell disease or trait. It helps determine if you may have inherited a gene linked to this condition.
["This screening helps identify if you carry the genetic mutation associated with sickle cell disease or trait."]
Key facts at a glance
- LOINC
- 46766-2
- Short code
- Hemoglobin SC Disease DBS-Imp
- Synonyms
- Hemoglobin SC Disease DBS-Imp
- Category
- hematology
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 12
- Ref high
- 17.5
- Critical range
- 7 N/A – 20 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 85018
- SNOMED
- 900000000000003004
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Matters
Sickle cell disease is a genetic blood disorder where red blood cells become misshapen and can block blood flow, causing pain, infections, and other complications. Screening is important for early detection, especially if you or your family have a history of sickle cell disease or trait.
How the Test Works
This test uses a simple blood sample to detect hemoglobin S through a qualitative method, often involving electrophoresis or another lab technique that separates different types of hemoglobin.
What to Expect Before the Test
You may have a small needle inserted into your arm to draw a blood sample. The process is quick and usually painless. No special preparation is needed, but inform your doctor if you are pregnant or have bleeding disorders.
What the Results Mean
A positive result means you have hemoglobin S in your blood, which may indicate sickle cell trait or disease. A negative result means you do not have this variant. Consult your healthcare provider for further evaluation if needed.
Reference range
Adult males: 13.5-17.5 g/dL; Females: 12.0-16.0 g/dLN/A
No special preparation required. Stay well hydrated.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
HbS Screening
Frequently asked questions
What does a positive result mean?
What does a negative result mean?
Can I get this test if I’m pregnant?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy