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Hemolysis Interference Index (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures how much red blood cells in your blood sample have broken open, which can interfere with other lab tests. It helps doctors check for conditions that cause red blood cell damage.

Quick summary

["This test helps identify if your blood sample contains too many broken red blood cells, which may affect other test results."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
97198-6
Short code
Hemolysis interf index CSF-aCnc
Synonyms
Hemolysis interf index CSF-aCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
86430
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why is this test done?

Your doctor may order this test if you have symptoms like fatigue, dark urine, or pale skin, or if certain lab results appear unusually high or low. It’s also used to monitor conditions that can cause red blood cells to break apart, such as certain blood disorders or reactions to medications.

How does hemolysis affect other tests?

When red blood cells break open, they release substances that can interfere with other blood tests, such as measuring enzymes, electrolytes, or proteins. This can lead to false results, making it harder for doctors to diagnose or treat your condition accurately.

What might cause a high hemolysis index?

A high hemolysis index could be due to conditions like hemolytic anemia, improper blood collection, or exposure to certain medications or chemicals. It may also occur if your blood sample was handled poorly before testing.

What does a high or low index mean?

A high index suggests your blood sample has more broken red blood cells than normal, which could mean your body is breaking them down too quickly or that your sample was contaminated. A low index means your blood sample is likely intact and not causing interference.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical significance: Hemolysis interference can lead to misleading lab results, potentially delaying or changing treatment decisions. It’s important to follow proper blood collection and handling procedures to avoid false positives or negatives.

Short name

Hemolysis Index

Frequently asked questions

How long does it take to get results from this test?
Results are typically available within 1 to 2 business days, depending on your lab’s processing schedule.
Can I eat or drink before this test?
No special diet or fasting is required for this test, but follow your doctor’s instructions for any other preparations.
Will this test hurt?
No, this test involves a simple blood draw, which may cause a slight pinch but is generally quick and painless.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy