Heparan Sulfate Proteoglycan Enzyme Activity (Serum/Plasma)
This test measures the activity of enzymes involved in the breakdown of heparan sulfate, a component of connective tissue and extracellular matrix. It may be used to assess metabolic or genetic conditions affecting these proteins.
["This test helps evaluate enzyme function linked to heparan sulfate metabolism."]
Key facts at a glance
- LOINC
- 24086-1
- Short code
- Heparan-N-Sulfatase WBC-cCnt
- Synonyms
- Heparan-N-Sulfatase WBC-cCnt
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 4.5
- Ref high
- 11
- Critical range
- 2 N/A – 30 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 85004
- SNOMED
- 900000000000003002
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you have symptoms or a family history suggestive of metabolic disorders, lysosomal storage diseases, or conditions affecting proteoglycan metabolism. It could also be part of a broader evaluation for genetic testing or research studies focused on enzyme activity.
What to Expect Before the Test
No special preparation is typically required. You may have a blood sample drawn from a vein in your arm. If you’re on blood thinners, inform your provider before the test to avoid unnecessary delays or complications.
What the Test Results Mean
Results are qualitative (present/absent) and indicate whether enzyme activity is detected in your sample. Abnormal results may suggest underlying metabolic or genetic conditions affecting heparan sulfate metabolism, but further testing or clinical correlation is needed.
Common Conditions Monitored
This test may be part of the diagnostic workup for lysosomal storage disorders, such as mucopolysaccharidosis (MPS), or other rare genetic conditions involving enzyme deficiencies. It’s not routinely used for general health screening.
Reference range
Adult: 4.5-11.0 x 10^9/LN/A
No special preparation required. Stay well hydrated.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Abnormal enzyme activity could indicate inherited metabolic disorders that disrupt normal tissue function. Early detection may help guide treatment options, though specific therapies depend on the underlying condition. Consult your provider for interpretation and next steps.
Short name
Heparan Sulfate Proteoglycan Activity
Frequently asked questions
What is heparan sulfate?
How is this test different from other blood tests?
Can this test be done at home?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy