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Hepcidin-25 (Serum) – Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of hepcidin-25, a small protein produced primarily in the bone marrow, that helps regulate iron levels in the body.

Quick summary

["Hepcidin-25 helps balance iron, which is vital for energy and red blood cell production."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
71386-7
Short code
Hepcidin-25 SerPl-sCnc
Synonyms
Hepcidin-25 SerPl-sCnc
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for conditions affecting iron metabolism, such as anemia, chronic kidney disease, or certain genetic disorders like hereditary hemochromatosis. It may also be used to monitor iron-related disorders in patients with unexplained fatigue or other symptoms linked to iron imbalance.

What Does the Test Involve?

A blood sample is drawn from a vein, usually in your arm. The sample is then sent to a lab for analysis. Hepcidin-25 levels are measured using a specialized laboratory technique to detect its precise concentration in your serum.

What Are Common Results and Interpretations?

Results are not typically provided as a single reference range since hepcidin levels can vary based on health status, age, and other factors. Your provider will interpret the results in the context of your medical history, symptoms, and other test results.

What Might Abnormal Results Mean?

Elevated hepcidin levels may suggest conditions like anemia due to chronic inflammation, kidney disease, or certain cancers. Low levels might indicate iron overload disorders, such as hereditary hemochromatosis, or conditions affecting iron absorption.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Hepcidin-25

Frequently asked questions

What factors could affect my hepcidin-25 test results?
Several factors may influence hepcidin levels, including overall health, diet (especially iron intake), medications (like blood pressure or heart medications), and underlying conditions like infections, inflammation, or kidney disease. Recent blood loss, pregnancy, or physical activity can also temporarily affect results.
How soon will I receive my results, and what should I do next?
Results timing varies by lab; your provider will contact you once they are ready. Follow their guidance on next steps, which may include further testing, lifestyle changes, or monitoring if needed. If you have concerns, discuss them with your healthcare team.
Can I prepare for this test in any way?
No special preparation is usually needed. Avoid heavy meals before the test, but light eating or drinking water is fine. If you’re taking medications, ask your provider whether to pause them temporarily—some may affect iron levels or lab results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy