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Hereditary Diffuse Gastric Cancer (HDGC) Gene Mutation Analysis, Blood

Published: August 9, 2026Updated: August 17, 2026

A blood-based genetic test that looks for variants associated with hereditary diffuse gastric cancer, an inherited condition that can raise the risk of stomach cancer.

Quick summary

["This test evaluates inherited genetic risk for certain types of stomach cancer."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
107546-4
Short code
Hered gast multi anl Bld/T
Synonyms
Hered gast multi anl Bld/T
Category
liver
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
10
Ref high
40
Critical range
— – 500 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
CPT
84484
SNOMED
302774002
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

Hereditary diffuse gastric cancer gene mutation analysis examines DNA from a blood sample for genetic variants associated with inherited diffuse gastric cancer. The genes included may vary by laboratory, although CDH1 is commonly involved.

Why might I need this test?

This test may be considered when there is a personal or family history of stomach cancer, especially diffuse gastric cancer at a young age. It may also be used when a relative has a disease-causing genetic variant or when a healthcare professional is evaluating a suspected inherited cancer syndrome.

How is the test performed?

A blood sample is collected, and the laboratory analyzes the DNA for relevant genetic variants. Results are usually reported as pathogenic or likely pathogenic, uncertain significance, or negative, depending on the laboratory.

How do I prepare for the test?

This test generally requires only a routine blood draw and usually no special preparation. A genetics professional may review your personal and family history before testing and explain the possible results and their implications.

Reference range

Adult: 10-40 U/LN/A

Specimen: whole-blood

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HDGC genetic testing

Frequently asked questions

Does a positive result mean I will definitely develop stomach cancer?
No. A pathogenic or likely pathogenic result indicates an increased risk, not a certainty of cancer. A genetics professional can help explain the estimated risk and recommended monitoring.
Can this blood test replace stomach screening or endoscopy?
No. Genetic testing does not detect existing cancer and does not replace recommended endoscopic screening. A clinician can advise whether screening should begin earlier or occur more often.
Should relatives also be tested?
That depends on the result and the genes included. If a disease-causing variant is identified, a genetics professional may recommend targeted testing for relatives.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy