Factor V Leiden and Prothrombin G20210A Mutation Screening Panel (Blood)
This blood test checks for genetic variations linked to an increased risk of blood clots. Certain inherited mutations can make blood clot more easily, increasing the chance of conditions like deep vein thrombosis or pulmonary embolism.
["This test helps identify genetic factors that may raise your risk of abnormal blood clotting."]
Key facts at a glance
- LOINC
- 105336-2
- Short code
- Hered throm dis multi analy Bld
- Synonyms
- Hered throm dis multi analy Bld
- Category
- chemistry
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- molgen
- CPT
- 86038
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What Does This Test Measure?
The test screens for two specific genetic mutations: Factor V Leiden and the Prothrombin G20210A variant. These mutations are inherited and can affect how blood clots form. Factor V Leiden is the most common inherited cause of thrombophilia, while the Prothrombin mutation is less common but still significant.
How Is the Sample Collected?
A small amount of blood will be drawn from a vein in your arm by a healthcare professional. This is a standard procedure and typically causes only mild discomfort.
Why Might This Test Be Ordered?
Your doctor may recommend this test if you have a history of blood clots, unexplained leg swelling, or a family history of clotting disorders. It may also be used if you are considering pregnancy and have a risk factor for clotting-related complications.
What Are the Possible Findings?
If either mutation is present, it indicates an inherited tendency toward blood clotting. If neither mutation is found, it means these specific genetic variations are not detected in this test. Additional testing or further evaluation may still be needed to assess overall risk.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Hereditary Thrombophilia Screening
Frequently asked questions
How Long Will I Need to Wait for Results?
What Are the Next Steps If I Have a Positive Result?
Can I Still Take Blood Thinners If I Have These Mutations?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy