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Hepatitis E Virus IgG Antibody, Serum (Quantitative Immunoassay)

Published: August 9, 2026Updated: August 16, 2026

This test detects antibodies in your blood that your immune system produces in response to the Hepatitis E virus. It helps determine if you’ve been exposed to the virus in the past.

Quick summary

["This test helps assess past infection with Hepatitis E virus, which can cause liver disease."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
104413-0
Short code
HEV IgG sp1 Titr Ser IA
Synonyms
HEV IgG sp1 Titr Ser IA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test measures the presence of IgG antibodies specific to Hepatitis E virus. IgG antibodies are typically produced after an initial infection and remain in your system for a longer period. This indicates that your body has encountered the virus before, even if you no longer have active symptoms or virus in your blood.

Why It’s Done

Doctors may order this test if you have symptoms of liver disease, travel history to regions where Hepatitis E is common, or if you’re at risk for infection (e.g., due to contaminated water exposure). It can also be used to confirm past infection in individuals who have recovered from Hepatitis E.

How It’s Performed

A blood sample is drawn from a vein in your arm. The sample is sent to a lab where it is analyzed using an immunoassay method to detect the specific antibodies. This process typically takes a few days to complete.

What the Results Mean

A positive result means you likely had Hepatitis E in the past and developed IgG antibodies. A negative result suggests no detectable antibodies, meaning either you’ve never been exposed or the test was done too early after exposure. Results should be interpreted by your healthcare provider in the context of your medical history and symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IgG Antibody to Hepatitis E Virus

Frequently asked questions

How long do I need to wait before retesting if I suspect recent exposure?
If you suspect recent exposure to Hepatitis E, retesting may not be necessary immediately unless you develop symptoms. IgG antibodies take time to develop after infection, so a negative result now doesn’t rule out past exposure. Consult your doctor for guidance on timing.
Can this test detect acute Hepatitis E infection?
No, this test specifically measures IgG antibodies, which appear after the acute phase of infection. For detecting active Hepatitis E, your doctor may order a different test, such as one for Hepatitis E virus RNA, which can identify the virus itself during acute illness.
What are the common symptoms of Hepatitis E?
Common symptoms of Hepatitis E include fever, fatigue, loss of appetite, nausea, abdominal pain, dark urine, light-colored stools, and jaundice (yellowing of the skin or eyes). Symptoms usually appear 2 to 9 weeks after exposure and can last for weeks to months. Some people may not have any symptoms.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy