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Hexadecanedioate/Creatinine [Mass Ratio] in Urine

Published: August 9, 2026Updated: August 16, 2026

A specialized urine test that measures the amount of hexadecanedioate relative to creatinine. It may be used with other tests when evaluating suspected metabolic or fatty-acid disorders.

Quick summary

["This test measures hexadecanedioate in urine relative to creatinine, helping assess certain metabolic conditions when interpreted with other laboratory results."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
48114-3
Short code
Hexadecanedioate/Creat Ur-sRto
Synonyms
Hexadecanedioate/Creat Ur-sRto
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

Hexadecanedioate is a dicarboxylic fatty acid that can be detected in urine. This test measures its amount compared with urine creatinine, which helps account for differences in urine concentration.

Why might I need this test?

This test may be ordered as part of an evaluation for suspected inborn errors of metabolism, fatty-acid oxidation disorders, or unexplained symptoms such as low blood sugar, vomiting, or episodes of altered consciousness. Results are usually interpreted together with other urine, blood, and genetic tests.

How is the test performed?

A urine specimen is collected and analyzed in the laboratory for hexadecanedioate and creatinine. The laboratory calculates the amount of hexadecanedioate relative to the amount of creatinine and reports the ratio.

How do I prepare for the test?

Follow the collection instructions provided by your healthcare professional, including whether a first-morning or timed urine sample is required. Do not fast or make other dietary changes unless specifically instructed to do so, as diet and medications can affect some urine measurements.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urine hexadecanedioate-to-creatinine ratio

Frequently asked questions

Is this a routine urine test?
No. It is a specialized biochemical test usually ordered when a metabolic disorder is being investigated.
Why is the result reported as a ratio?
Comparing hexadecanedioate with creatinine helps account for how concentrated or dilute the urine sample is. This makes results easier to compare between samples.
Does an abnormal result confirm a metabolic disorder?
No. An abnormal result identifies a possible issue but does not confirm a diagnosis by itself. Additional blood, urine, imaging, or genetic testing may be needed.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy