Serum Hexosaminidase Activity (with Fibrinogen Measurement)
This test measures the activity of an enzyme called hexosaminidase in your blood, along with the level of fibrinogen—a protein involved in blood clotting. It may be used to diagnose or monitor certain genetic conditions.
["This test helps assess enzyme activity and protein levels linked to blood disorders or metabolic conditions."]
Key facts at a glance
- LOINC
- 25832-7
- Short code
- Hexosaminidase A Act Fib-Imp
- Synonyms
- Hexosaminidase A Act Fib-Imp
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you have symptoms or a family history suggestive of conditions like **Gaucher disease** (a genetic disorder affecting storage of certain fats in cells) or other lysosomal storage disorders. It could also be part of a broader evaluation for bleeding disorders or inherited clotting issues.
What to Expect Before the Test
No special preparation is typically needed. You may fast for 8–12 hours before the draw if instructed, but always follow your provider’s specific instructions. Bring any medications or supplements you’re taking to your appointment.
How the Test Is Performed
A healthcare professional will draw blood from a vein in your arm using a small needle. The blood sample will be sent to a lab where it is analyzed for hexosaminidase enzyme activity and fibrinogen levels using specialized laboratory techniques.
What the Results Mean
Results are interpreted by your healthcare provider based on your medical history, symptoms, and lab values. Abnormal enzyme activity or fibrinogen levels may indicate underlying conditions requiring further evaluation, such as genetic disorders or clotting dysfunctions.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Elevated or reduced hexosaminidase activity can signal lysosomal storage disorders (e.g., Gaucher disease), where enzymes fail to break down certain substances properly. Fibrinogen levels may also be monitored for bleeding disorders or inherited clotting abnormalities. Always discuss results with your provider for personalized interpretation.
Short name
Hexosaminidase Activity
Frequently asked questions
What causes abnormal hexosaminidase activity?
How long does it take to get results?
Can I take my medications before the blood draw?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy