Skip to content

Hexosaminidase activity in serum/plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the activity of an enzyme called hexosaminidase, which plays a role in breaking down certain sugars in the body. It is often used to help diagnose genetic conditions affecting metabolism.

Quick summary

["This test helps identify potential genetic metabolic disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
1957-0
Short code
Hexosaminidase B SerPl-cCnc
Synonyms
Hexosaminidase B SerPl-cCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Hexosaminidase?

Hexosaminidase is an enzyme found in many cells, including those in the brain and liver. It helps process certain sugars (glycosphingolipids) that are important for cell function. Abnormal levels can indicate inherited metabolic disorders like Tay-Sachs disease.

Why Might This Test Be Ordered?

Your healthcare provider may order this test if you have symptoms like developmental delays, seizures, or muscle weakness, or if there is a family history of metabolic disorders. It’s also sometimes checked in newborn screening programs.

How Is the Sample Collected?

A blood sample is drawn from a vein, usually in your arm. The blood is then separated into serum or plasma for testing. This process is quick and typically done in a clinic or lab setting.

What Does the Test Result Mean?

Results are not always given as a single number because the test measures enzyme activity rather than a specific substance concentration. Your provider will interpret the results in relation to your symptoms and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Hexosaminidase

Frequently asked questions

What are the normal ranges for this test?
Normal ranges can vary by lab and method, so your results will be reviewed by a healthcare provider who can compare them to your specific situation. Abnormally low levels may suggest genetic disorders affecting enzyme function.
How often should I get this test?
This test is usually done once or as part of a specific diagnostic evaluation. Follow your healthcare provider’s instructions for follow-up testing if needed.
What can I do to prepare for this test?
No special preparation is needed for this blood test. However, avoid eating or drinking anything (except water) for a few hours before the draw if instructed by your provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy