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Hemoglobin mass concentration in whole blood by mass spectrometry

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of hemoglobin, the protein in red blood cells that carries oxygen, using a specialized blood test.

Quick summary

["Helps assess red blood cell health and potential blood disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
76769-9
Short code
Hgb BldV Oximetry-mCnc
Synonyms
Hgb BldV Oximetry-mCnc
Category
hematology
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
12
Ref high
17.5
Critical range
7 N/A – 20 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
oximetry
CPT
85018
SNOMED
900000000000003004
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Your doctor may order this test to help diagnose a medical condition, check how well an organ is working, or monitor an existing health problem. It can also be used to confirm findings from other tests or to guide decisions about your treatment plan.

Your healthcare provider may recommend this test if you have symptoms like fatigue, pale skin, shortness of breath, or if they suspect conditions such as anemia, blood loss, or other blood-related disorders. It can also be part of routine blood checks or before certain treatments.

Before the test, your healthcare provider will explain the procedure and give you specific instructions. You may need to adjust certain medications, avoid food or drinks for a set period of time, or arrange for someone to drive you home afterward. Be sure to tell your care team about any allergies, medications, supplements, or health conditions you have.

No special preparation is usually needed. You may fast before the test if instructed, but this is not always required. Bring any medications you’re taking to your appointment.

During the test, a trained member of your care team will guide you through each step and let you know what to do. The procedure is usually quick, and most people feel little more than mild discomfort. If you feel pain, dizziness, or anxiety at any point, tell the staff right away so they can help you stay comfortable.

A healthcare professional will draw blood from a vein in your arm. You may feel a slight pinch, but it typically doesn’t cause significant discomfort. The blood sample is then sent to a lab for analysis using advanced mass spectrometry.

Your results will show whether your values fall within the normal range for this test. Results that are higher or lower than expected may point to a condition that needs further evaluation, but they do not always mean something is seriously wrong. Your doctor will review the findings with you, explain what they mean in the context of your overall health, and discuss any follow-up testing or treatment that may be needed.

Results provide the total hemoglobin mass in your blood, which can help diagnose or monitor conditions affecting red blood cells. While reference ranges vary by lab, lower than expected levels may indicate anemia or blood loss, while higher levels could suggest conditions like polycythemia.

Reference range

Adult males: 13.5-17.5 g/dL; Females: 12.0-16.0 g/dLN/A

Specimen: whole-blood

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Hemoglobin Mass (Whole Blood)

Frequently asked questions

Hemoglobin mass concentration is important for diagnosing and managing anemia, evaluating blood loss, and assessing red blood cell production. It can also help guide treatment decisions for conditions like chronic kidney disease or certain cancers.
Most results are ready within a few days, although some tests can take a week or longer. Your doctor's office will contact you as soon as the results are available, or you can check your patient portal. If you have not heard back within the expected time frame, call the office to ask about your results.
Results are typically available within 24 to 48 hours, depending on lab processing times. Your healthcare provider will contact you with the results and any follow-up steps.
Fasting requirements depend on the specific test your doctor has ordered. Some tests require you to avoid food and drinks, except water, for 8 to 12 hours beforehand, while others need no preparation at all. Follow the instructions your care team gives you, and ask ahead of time if you are unsure whether fasting applies to your test.
No, fasting is not always required for this test. However, follow your healthcare provider’s instructions if they specify any preparation, such as avoiding certain medications or foods.
Yes, you can take your usual medications as scheduled unless your healthcare provider advises otherwise. Always inform them about any medications, supplements, or over-the-counter drugs you’re taking.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy