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Hemoglobin A1c (HbA1c) with Mass Fraction Measurement

Published: August 9, 2026Updated: August 16, 2026

This test measures the percentage of hemoglobin that is coated with sugar (glycated hemoglobin), reflecting your average blood sugar levels over the past 2–3 months.

Quick summary

["HbA1c helps track long-term diabetes control and glucose management."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
54073-2
Short code
Hgb C MFr DBS
Synonyms
Hgb C MFr DBS
Category
hematology
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
12
Ref high
17.5
Critical range
7 N/A – 20 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85018
SNOMED
900000000000003004
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What HbA1c Test Measures

HbA1c measures the proportion of hemoglobin molecules that have sugar (glucose) attached. This attachment happens when blood sugar levels are consistently high over time. The test provides a snapshot of your average blood sugar levels during the red blood cell’s lifespan (typically 2–3 months).

Why This Test Matters

HbA1c is crucial for diagnosing diabetes and managing blood sugar levels. It helps doctors assess whether your treatment plan is effective and adjusts it as needed to prevent complications like nerve damage, kidney disease, or heart problems.

How the Test Works

Blood is drawn, and the hemoglobin is separated from other blood components. The test then measures the fraction of hemoglobin that has sugar attached, using specialized laboratory techniques to quantify this glycation.

Common Uses

Doctors use HbA1c to diagnose type 1 and type 2 diabetes, monitor pre-diabetes, and evaluate long-term diabetes management. It’s also useful for assessing how well diabetes medications or lifestyle changes are working.

Reference range

Adult males: 13.5-17.5 g/dL; Females: 12.0-16.0 g/dLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

HbA1c

Frequently asked questions

HbA1c is a reliable indicator of blood sugar control because it reflects long-term glucose exposure. While individual results can vary slightly, consistent trends help guide treatment decisions and reduce the risk of diabetes-related complications.
HbA1c results are typically reported as a percentage (e.g., 6.5%). A result below 5.7% is generally considered normal, while 5.7%–6.4% indicates prediabetes. A result of 6.5% or higher often confirms diabetes diagnosis.
How often should I get this test?
For people without diabetes, HbA1c testing is often recommended every 1–2 years. Those with diabetes typically get it every 2–3 months to monitor progress and adjust treatment. Your doctor will determine the best schedule for you.
What factors can affect my HbA1c results?
Several factors may influence HbA1c, including recent blood loss, severe illness, or changes in diet/exercise. Smoking can also temporarily lower HbA1c, so it’s best to avoid smoking for a few weeks before testing.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy