Hemoglobin Fraction Analysis (Erythrocyte Mass Fraction by Blood Cell Subpopulation)
This test measures the proportion of different hemoglobin types in your red blood cells, which can help identify conditions affecting blood composition.
["Understanding your hemoglobin types helps diagnose anemia or blood disorders."]
Key facts at a glance
- LOINC
- 4575-7
- Short code
- Hgb E MFr Bld
- Synonyms
- Hgb E MFr Bld
- Category
- hematology
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Ref low
- 12
- Ref high
- 17.5
- Critical range
- 7 N/A – 20 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 85018
- SNOMED
- 900000000000003004
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
The test analyzes the mass fraction of hemoglobin variants in your blood, breaking down red blood cells into distinct subpopulations (e.g., fetal hemoglobin, abnormal hemoglobin forms). This helps assess how different hemoglobin types contribute to overall blood function.
Why It’s Done
Doctors may order this test if you have symptoms like fatigue, pale skin, or unusual blood test results. It’s also used to monitor conditions like sickle cell disease, thalassemia, or other inherited blood disorders.
How It Works
Blood is drawn and analyzed using advanced techniques to separate hemoglobin into its components. The results show the relative amounts of each type, helping identify any imbalances.
Common Conditions Monitored
This test is particularly useful for diagnosing or managing conditions where hemoglobin structure varies, such as hereditary hemolytic anemias or hemoglobinopathies (e.g., sickle cell trait or disease).
Reference range
Adult males: 13.5-17.5 g/dL; Females: 12.0-16.0 g/dLN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Abnormal hemoglobin fractions can indicate genetic disorders, iron deficiency, or other blood-related issues. High or low levels of certain hemoglobin types may signal underlying health risks that require further evaluation.
Short name
Hemoglobin Fraction Test
Frequently asked questions
What does a high or low hemoglobin fraction mean?
Does this test require fasting?
How long does it take to get results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy