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Serum or plasma concentration of free bilirubin

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of bilirubin that is not bound to proteins in your blood. Bilirubin is a yellow pigment produced when red blood cells break down.

Quick summary

["Free bilirubin helps diagnose liver or bile duct issues and monitor conditions like jaundice."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
28067-7
Short code
Hgb F Amn Ql
Synonyms
Hgb F Amn Ql
Category
hematology
Sample
fluid
Container
Sterile tube
Units
N/A
Ref low
12
Ref high
17.5
Critical range
7 N/A – 20 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85018
SNOMED
900000000000003004
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

Why This Test Matters

Your doctor may order this test to check for liver disease, bile duct blockages, or other conditions that affect how your body processes bilirubin. High levels can indicate problems like hepatitis, gallstones, or certain blood disorders.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into a vein in your arm to draw blood. If you’re fasting, follow your doctor’s instructions about when to eat or drink.

What the Results Mean

Results are compared to a standard range, but exact values depend on your health and lab. High levels may signal liver or bile duct problems, while low levels could be normal or due to certain medications.

Common Conditions Monitored

This test is often used to diagnose or monitor conditions like jaundice (yellowing of skin/eyes), liver disease, or hemolytic anemia (red blood cell breakdown). It can also help track treatment progress.

Reference range

Adult males: 13.5-17.5 g/dL; Females: 12.0-16.0 g/dLN/A

Specimen: fluid

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated free bilirubin can signal liver dysfunction, bile duct obstructions, or red blood cell disorders. Doctors may also check it after certain surgeries or treatments to ensure your body is processing bilirubin correctly. Low levels alone usually aren’t concerning unless paired with other symptoms or medical history.

Short name

Free bilirubin

Frequently asked questions

How is this test different from total bilirubin?
Free bilirubin measures only the unbound (unconjugated) form, while total bilirubin includes both free and protein-bound bilirubin. Your doctor may use both tests together for a fuller picture.
What causes free bilirubin to rise?
Common causes include liver disease (like hepatitis), bile duct blockages (e.g., gallstones), hemolytic anemia, or certain medications. Always discuss symptoms or risk factors with your doctor.
Can diet affect free bilirubin test results?
Dietary changes alone rarely affect free bilirubin levels, but fasting may be required before the test. Avoid alcohol or certain medications (e.g., antibiotics) unless instructed by your doctor.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy