Hemoglobin F Percentage by Electrophoresis (Blood)

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms of blood disorders, such as fatigue, pale skin, or unusual pain. It may also be used to screen for genetic blood conditions in newborns or during pregnancy. Some people with certain blood types or ethnic backgrounds are at higher risk and may need this test as part of routine monitoring.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm to draw a blood sample. The process usually takes a few minutes, and you may feel a brief pinch or discomfort. If you’re pregnant, let your provider know before the test.

What the Test Results Mean

Results show the proportion of HbF relative to other hemoglobin types. Higher-than-normal levels may indicate conditions like beta-thalassemia or sickle cell trait, while lower levels may suggest other blood disorders. Your provider will interpret results in the context of your symptoms and medical history.

Common Conditions Monitored

This test is often used to diagnose or monitor conditions such as beta-thalassemia (a genetic blood disorder), sickle cell disease (a genetic blood disorder causing red blood cells to become misshapen), or fetal hemoglobin levels in adults with certain blood disorders.