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Hemoglobin A1c (HbA1c) with 24-hour urine collection for total 24-hour urinary excretion of free hemoglobin

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of free hemoglobin excreted in your urine over 24 hours, which can help assess how much hemoglobin is being broken down in your body.

Quick summary

["This test may help identify conditions affecting red blood cell breakdown or kidney function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
4631-8
Short code
Hgb F Stl Ql Apt-Downey
Synonyms
Hgb F Stl Ql Apt-Downey
Category
hematology
Sample
stool
Container
Clean container
Units
N/A
Ref low
12
Ref high
17.5
Critical range
7 N/A – 20 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
apt-downey
CPT
85018
SNOMED
900000000000003004
Specimen volume
5 g
Stability
Refrigerated: 24h, Frozen: 7d
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if they suspect conditions like hemolysis (destruction of red blood cells), certain kidney diseases, or to monitor hemoglobin-related disorders. It can also be part of broader evaluations for anemia or unexplained fatigue.

What to Expect Before the Test

You’ll collect your urine over a full 24-hour period, typically starting after a bathroom trip in the morning. Store the urine in a refrigerator and return it to the lab on time. Drink plenty of fluids to ensure adequate urine volume.

What the Test Involves

The lab analyzes the urine sample for free hemoglobin, which is a breakdown product of hemoglobin. This test does not require fasting or special preparation beyond the urine collection.

What the Results Mean

Results are interpreted in the context of your overall health, symptoms, and other tests. Elevated levels may indicate conditions like hemolysis or kidney issues, while normal levels suggest stable red blood cell breakdown.

Reference range

Adult males: 13.5-17.5 g/dL; Females: 12.0-16.0 g/dLN/A

Specimen: stool

Inform your healthcare provider if you are taking blood thinners. No special preparation required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HbA1c Urinary Free Hemoglobin 24h

Frequently asked questions

What does a high level of free hemoglobin in urine mean?
High levels may signal conditions such as hemolytic anemia (where red blood cells break down faster than the body can replace them), certain kidney diseases, or excessive muscle breakdown (rhabdomyolysis). Your provider will discuss these findings with you.
What does a low level of free hemoglobin in urine mean?
Low levels typically suggest normal red blood cell turnover or that the test may not be appropriate for your situation (e.g., if you have severe kidney disease that affects urine collection). Further evaluation may be needed.
How often should I get this test?
Your provider will determine the frequency based on your medical history, symptoms, and other tests. Follow-up may be needed if initial results are abnormal or if you have ongoing concerns about red blood cell health.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy