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Albumin and Total Protein Electrophoresis (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the levels of albumin and total protein in your blood using electrophoresis, a method that separates different protein types based on size and charge.

Quick summary

["Helps assess liver function, kidney health, and overall protein balance in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
4578-1
Short code
Hgb F-Texas Bld Elph Alk-aCnc
Synonyms
Hgb F-Texas Bld Elph Alk-aCnc
Category
hematology
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
12
Ref high
17.5
Critical range
7 N/A – 20 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
electrophoresis-ph
CPT
85018
SNOMED
900000000000003004
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test to check for conditions affecting protein production, such as liver disease, kidney problems, malnutrition, or certain blood disorders. It can also help monitor treatment progress for conditions like nephrotic syndrome or chronic liver disease.

How the Test Works

A small blood sample is taken from a vein in your arm. The blood is then processed to separate proteins, which are analyzed using electrophoresis. This technique separates proteins into bands, allowing for comparison against known standards to estimate albumin and total protein levels.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for a few hours if your provider specifies. Wear comfortable clothing and plan for a short visit to the lab.

What to Expect During the Test

The test involves a quick, minor blood draw from your arm. You may feel a slight pinch, but it typically takes only a few minutes. You can usually return to normal activities immediately afterward.

Reference range

Adult males: 13.5-17.5 g/dL; Females: 12.0-16.0 g/dLN/A

Specimen: whole-blood

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Albumin & Protein Electrophoresis

Frequently asked questions

What Does a Low or High Albumin Level Mean?
A low albumin level may suggest liver or kidney issues, malnutrition, or excessive protein loss (e.g., from kidney disease). A high level could indicate dehydration or conditions that reduce protein breakdown.
How Often Should This Test Be Done?
Frequency depends on your health condition. Routine checks may occur every few months for chronic conditions like liver disease or kidney problems, while acute cases may require more frequent testing.
Can Diet Affect Albumin or Protein Levels?
Yes, diet plays a role. High-protein diets or deficiencies in essential amino acids can influence protein levels, while poor nutrition (e.g., low calories) may lower albumin. Your provider may recommend dietary adjustments if needed.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy