Serum Hemoglobin Electrophoresis (for Hemoglobin F and A variants)
This test measures the types of hemoglobin in your blood, including the fraction of fetal hemoglobin (HbF). It helps identify certain blood disorders or genetic conditions.
["This test helps diagnose conditions related to abnormal hemoglobin."]
Key facts at a glance
- LOINC
- 4589-8
- Short code
- Hgb Hashar Bld Ql Elph Acid
- Synonyms
- Hgb Hashar Bld Ql Elph Acid
- Category
- hematology
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Ref low
- 12
- Ref high
- 17.5
- Critical range
- 7 N/A – 20 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- electrophoresis-ph
- CPT
- 85018
- SNOMED
- 900000000000003004
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
Hemoglobin electrophoresis separates different hemoglobin types based on their electrical charge. The test specifically looks at the proportion of fetal hemoglobin (HbF) and other hemoglobin variants, which can be useful in conditions like thalassemia or sickle cell disease.
Why It’s Done
Your healthcare provider may order this test if you have symptoms like anemia, fatigue, or if you have a family history of hemoglobin disorders. It can also be used during pregnancy to screen for fetal hemoglobin levels.
Sample Collection and Preparation
A small blood sample is taken from your arm. The blood is processed to separate hemoglobin components, which are then analyzed using electrophoresis.
What to Expect Before the Test
No special preparation is needed, but inform your provider about any medications you’re taking, especially blood thinners or supplements like iron.
Reference range
Adult males: 13.5-17.5 g/dL; Females: 12.0-16.0 g/dLN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Abnormal levels of fetal hemoglobin (HbF) or other hemoglobin variants can indicate genetic blood disorders. High HbF levels may be seen in conditions like beta-thalassemia or during pregnancy. Low levels of specific hemoglobin types can point to hereditary conditions affecting red blood cell production.
Short name
Hemoglobin electrophoresis
Frequently asked questions
When might I need this test?
What does the test result mean?
Can I eat or drink before the test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy