Skip to content

Serum Hemoglobin Electrophoresis (for Alpha-1 Antitrypsin and Related Proteins)

Published: August 9, 2026Updated: August 16, 2026

This test measures the distribution of hemoglobin variants and proteins in your blood, including Alpha-1 Antitrypsin, which helps assess conditions affecting red blood cells or protein metabolism.

Quick summary

["This test helps identify potential genetic or acquired blood disorders by examining protein patterns in your blood sample."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
4590-6
Short code
Hgb Hashar Bld Ql Elph Alk
Synonyms
Hgb Hashar Bld Ql Elph Alk
Category
hematology
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
3.5
Ref high
5
Critical range
7 N/A – 20 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
electrophoresis-ph
CPT
84132
SNOMED
110742001
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

This test measures the levels of specific substances in your blood, helping your doctor evaluate how well certain organs and body systems are working and identify potential health concerns.

The test uses electrophoresis to separate hemoglobin and other blood proteins based on their electrical charge. This helps identify abnormal hemoglobin forms or protein levels that may indicate conditions like sickle cell disease, thalassemia, or hereditary hemolytic anemia.

Your doctor may order this test to help diagnose a medical condition, monitor an ongoing health problem, or check how well your current treatment plan is working for you.

Your healthcare provider may order this test if you have symptoms like fatigue, anemia, or unexplained blood abnormalities. It’s also used in research or screening for inherited blood disorders.

A trained healthcare professional will collect a small sample, typically a blood draw from a vein in your arm, and the entire collection process usually takes only a few minutes.

A blood sample is drawn from a vein, typically in your arm. The sample is processed to separate serum for testing.

Most people can follow their normal daily routine before this test, but it is always a good idea to confirm any specific instructions with your doctor ahead of time.

No special preparation is needed for this test, and fasting is generally not required unless your doctor has specifically instructed you not to eat or drink beforehand.

Reference range

Adult: 3.5-5.0 mmol/LN/A

Specimen: whole-blood

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Abnormal results may indicate genetic disorders (e.g., alpha-1 antitrypsin deficiency), hemoglobinopathies (e.g., sickle cell trait), or other blood-related conditions. This test supports diagnosis and management of inherited or acquired blood disorders.

Short name

Hemoglobin Electrophoresis

Frequently asked questions

What does an abnormal result mean?
An abnormal result may suggest an inherited blood disorder, abnormal hemoglobin forms, or protein metabolism issues. Your doctor will discuss findings with you and may recommend further testing or monitoring.
How long does it take to get results?
Results are typically available within 24 to 72 hours, depending on lab processing times. Follow-up with your healthcare provider to interpret results and next steps.
Is this test painful?
The blood draw may cause mild discomfort or bruising, but most people tolerate it well. Pain is usually short-lived, and ice can help reduce swelling afterward.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy