Hemoglobin Electrophoresis (Sickle Cell Screening)
This blood test checks for abnormal hemoglobin variants, including sickle hemoglobin (HbS), which can cause conditions like sickle cell disease or sickle cell trait.
["Helps identify genetic risks for blood disorders that may affect oxygen transport in your body."]
Key facts at a glance
- LOINC
- 94538-6
- Short code
- Hgb HPLC + electrophoresis Pnl Bld
- Synonyms
- Hgb HPLC + electrophoresis Pnl Bld
- Category
- hematology
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 12
- Ref high
- 17.5
- Critical range
- 7 N/A – 20 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 85018
- SNOMED
- 900000000000003004
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Your doctor may recommend this test if you have a family history of sickle cell disease, live in an area with higher prevalence of sickle cell traits, or experience symptoms like fatigue, pain, or frequent infections. It’s also part of routine newborn screening in some regions.
What to Expect Before the Test
You’ll have a small needle inserted into your arm to draw a small amount of blood. The test is quick and usually done in a lab setting. No special preparation is needed, but avoid eating or drinking for a short time before if instructed.
What Happens During the Test
The blood sample is analyzed using electrophoresis, a method that separates different types of hemoglobin based on their electrical charge. This helps identify any abnormal hemoglobin variants.
Results and Interpretation
Results are typically reported as either positive or negative for sickle hemoglobin or other variants. A positive result means you have a higher risk of sickle cell traits or disease, which may guide further testing or monitoring.
Reference range
Adult males: 13.5-17.5 g/dL; Females: 12.0-16.0 g/dLN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Detecting sickle hemoglobin early can help manage symptoms, prevent complications, and inform genetic counseling. Sickle cell trait (HbAS) is usually harmless but may cause mild symptoms under stress or dehydration. Sickle cell disease (HbSS) is a severe genetic disorder requiring lifelong management.
Short name
Sickle Cell Trait/Sickle Cell Disease Screening
Frequently asked questions
What does a positive result mean?
How often should I get this test?
Can lifestyle changes help if I have sickle cell trait?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy