Hemoglobin M Disease Screening (Mass Fraction of Hemoglobin in Red Blood Cells)
This test helps detect abnormal hemoglobin variants, which can cause red blood cells to break down prematurely and lead to anemia or other blood disorders.
["Screening for rare hemoglobin disorders that may affect red blood cell health and function."]
Key facts at a glance
- LOINC
- 51614-6
- Short code
- Hgb M MFr Bld
- Synonyms
- Hgb M MFr Bld
- Category
- hematology
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Ref low
- 12
- Ref high
- 17.5
- Critical range
- 7 N/A – 20 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 85018
- SNOMED
- 900000000000003004
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What Is Hemoglobin M Disease?
Hemoglobin M disease is a genetic condition where your red blood cells produce an abnormal form of hemoglobin (the protein that carries oxygen). This variant can cause the cells to break down too soon, leading to anemia or other complications. The test measures the mass fraction of this abnormal hemoglobin in your blood.
Why Might You Need This Test?
Your healthcare provider may recommend this screening if you have symptoms like fatigue, weakness, or unusual pale skin, or if you have a family history of hemoglobin disorders. It’s also used as part of genetic testing for inherited blood conditions.
How Is the Test Performed?
A small blood sample is drawn from a vein in your arm. The test analyzes the hemoglobin composition in your red blood cells using mass fraction measurement techniques.
What Do the Results Mean?
Results may indicate the presence of abnormal hemoglobin variants. If elevated or abnormal levels are found, further genetic testing may be needed to confirm the diagnosis and guide treatment.
Reference range
Adult males: 13.5-17.5 g/dL; Females: 12.0-16.0 g/dLN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Hemoglobin M Screening
Frequently asked questions
What are the normal results for this test?
Can this test be done at home?
How often should I get this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy