Hemoglobin M variant screening (qualitative electrophoresis)
This test checks for the presence of an abnormal hemoglobin variant called M, which can cause anemia or other blood-related symptoms. Hemoglobin M is a rare genetic condition where the red blood cells may appear pale or may break apart easily.
["This test helps identify if you have a genetic condition affecting your red blood cells."]
Key facts at a glance
- LOINC
- 109484-6
- Short code
- Hgb Msmt BldA
- Synonyms
- Hgb Msmt BldA
- Category
- hematology
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Ref low
- 12
- Ref high
- 17.5
- Critical range
- 7 N/A – 20 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 85018
- SNOMED
- 900000000000003004
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What Does This Test Measure?
The test uses electrophoresis, a method that separates different types of hemoglobin based on their electrical charge. If an abnormal hemoglobin M variant is present, it will appear differently on the electrophoresis results compared to normal hemoglobin.
Why Might You Need This Test?
This test may be recommended if you have symptoms like fatigue, pale skin, weakness, or unexplained anemia. It could also be part of a genetic screening if you have a family history of hemoglobin disorders or specific blood conditions.
How Is the Sample Collected?
A small amount of blood will be drawn from a vein in your arm by a healthcare professional. This is usually done in a clinic or lab setting.
What Are Possible Results?
If the test result shows an abnormal pattern on electrophoresis consistent with hemoglobin M, it indicates a positive finding for this variant. If the result is normal, no abnormal hemoglobin M variant is detected.
Reference range
Adult males: 13.5-17.5 g/dL; Females: 12.0-16.0 g/dLN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Hemoglobin M variants can lead to hemolytic anemia, where red blood cells break down more easily than normal. This can cause fatigue, shortness of breath, and other symptoms. Early detection helps manage symptoms and plan appropriate treatment or monitoring.
Short name
Hemoglobin M screening
Frequently asked questions
What does a positive result mean?
How is this test different from a regular hemoglobin test?
Can this test be done at home?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy