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Hemoglobin Electrophoresis (Sickle Cell Screening)

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of abnormal hemoglobin variants, including sickle hemoglobin (HbS), which can affect red blood cells and may lead to sickle cell disease or sickle cell trait.

Quick summary

["Helps identify whether you carry genes for sickle cell trait or disease, which can influence health risks and treatment options."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
4622-7
Short code
Hgb S Bld Ql Elph Acid
Synonyms
Hgb S Bld Ql Elph Acid
Category
hematology
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
12
Ref high
17.5
Critical range
7 N/A – 20 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
electrophoresis-ph
CPT
85018
SNOMED
900000000000003004
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What This Test Measures

The test uses electrophoresis to separate different types of hemoglobin in your blood. This method helps detect variations, such as sickle hemoglobin (HbS), which is linked to sickle cell trait or disease. Normal hemoglobin (HbA) is the most common form, but other variants may also be present.

Why It’s Done

Doctors may recommend this test if you have a family history of sickle cell disease, are from regions where the condition is more common, or are considering pregnancy. It can also be part of newborn screening in some areas.

Sample Collection

A small blood sample is taken from your arm using a needle. The blood is then processed to separate hemoglobin variants for analysis.

What to Expect Before the Test

No special preparation is needed, but inform your healthcare provider if you’re taking blood thinners or have a history of bleeding disorders.

Reference range

Adult males: 13.5-17.5 g/dL; Females: 12.0-16.0 g/dLN/A

Specimen: whole-blood

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Sickle Cell Trait/Sickle Cell Disease Screening

Frequently asked questions

Will this test affect my insurance or medical coverage?
This test is typically covered by insurance if medically necessary, such as for genetic screening or prenatal care. Always check with your insurance provider for specifics.
How long does it take to get results?
Results are usually available within 1–3 business days, depending on lab processing times.
Can I fast before this test?
No fasting is required for this blood test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy