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Hemoglobin Mass Concentration in Red Blood Cells (by Flow Cytometry)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of hemoglobin inside your red blood cells, which can help assess iron stores and red blood cell health.

Quick summary

["Helps check for iron deficiency or anemia by examining hemoglobin inside cells."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
726-0
Short code
Hgb Ur-mCnc
Synonyms
Hgb Ur-mCnc
Category
hematology
Sample
urine
Container
Sterile urine container
Units
N/A
Ref low
12
Ref high
17.5
Critical range
7 N/A – 20 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85018
SNOMED
900000000000003004
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Matters for Your Health

Hemoglobin is the protein in red blood cells that carries oxygen. When your body doesn’t produce enough hemoglobin or when red blood cells are damaged, it can lead to anemia or other blood-related conditions. This test specifically looks at the hemoglobin *within* your red blood cells, not just the total hemoglobin in your bloodstream.

How the Test Works

Your blood sample is analyzed using flow cytometry, a technique that measures the size, shape, and internal components of red blood cells. This test focuses on the hemoglobin mass inside each cell, which can be affected by conditions like iron deficiency, hemolytic anemia, or certain genetic disorders.

Common Reasons for Testing

Doctors may order this test if you have symptoms like fatigue, pale skin, shortness of breath, or if lab results suggest low red blood cell counts or abnormal hemoglobin levels. It can also be part of a broader evaluation for unexplained anemia or iron studies.

What to Expect Before the Test

No special preparation is needed, but you may fast for 8–12 hours before the test if your blood is drawn early in the morning. Wear a loose-fitting shirt for easy access to your arm.

Reference range

Adult males: 13.5-17.5 g/dL; Females: 12.0-16.0 g/dLN/A

Specimen: urine

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Hemoglobin RBC Mass

Frequently asked questions

What does a low or high hemoglobin RBC mass mean?
A lower than expected hemoglobin RBC mass may indicate iron deficiency (where your body doesn’t have enough iron to make hemoglobin), hemolytic anemia (where red blood cells break down too quickly), or other blood disorders. A higher than expected value could suggest conditions like polycythemia (too many red blood cells) or certain genetic disorders.
How does this test differ from a standard hemoglobin test?
Unlike a standard hemoglobin test, which measures total hemoglobin in your blood, this test specifically looks at the hemoglobin *inside* red blood cells. It provides a more detailed picture of your red blood cell health and can help identify issues with hemoglobin production or cell integrity.
Can this test be done at home?
No, this test requires a blood sample drawn in a clinical setting by a healthcare professional. Results are typically reported within 1–3 business days, depending on your lab.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy