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Serum or plasma concentration of human insulin-like growth factor 1 (IGF-1)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of IGF-1, a protein produced by the liver in response to growth hormone, which plays a key role in growth, cell repair, and metabolism.

Quick summary

["IGF-1 helps assess growth hormone function and potential growth or metabolic issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
7393-2
Short code
H interseminatum IgE Qn
Synonyms
H interseminatum IgE Qn
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order an IGF-1 test to evaluate growth problems in children, monitor growth hormone treatment, or investigate symptoms like slow growth, short stature, or metabolic disorders. It can also help diagnose conditions affecting hormone regulation, such as pituitary disorders.

What to Expect Before the Test

No special preparation is usually needed. You may be asked to fast for 8–12 hours before the test, but this depends on your healthcare provider’s instructions. Bring any medications you’re taking to your appointment.

How the Test Is Performed

A blood sample is drawn from a vein in your arm. You may feel a small pinch, but it typically doesn’t cause discomfort. The sample is sent to a lab for analysis.

What the Results Mean

Results are interpreted based on your age, sex, and overall health. Low IGF-1 levels may suggest growth hormone deficiency, while high levels could indicate overproduction or certain medical conditions. Your provider will discuss findings with you.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IGF-1 Level

Frequently asked questions

What causes IGF-1 levels to be low?
Low IGF-1 levels are often linked to growth hormone deficiency, genetic disorders, malnutrition, or chronic illnesses like liver disease or kidney problems. Some medications or thyroid disorders may also affect IGF-1.
What causes IGF-1 levels to be high?
High IGF-1 levels can result from growth hormone excess (e.g., acromegaly), certain tumors (e.g., pituitary adenomas), or genetic conditions. Rarely, it may occur with kidney disease or liver dysfunction.
How often should IGF-1 testing be repeated?
Follow-up testing depends on your symptoms and initial results. Your provider may recommend retesting if treatment is needed or if signs of imbalance persist, typically every few months or as advised.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy