Hippurate (Hippuric Acid) and Creatinine, 24-Hour Urine
Measures hippurate, a metabolite of several chemicals, and creatinine in urine collected for 24 hours. Creatinine helps account for urine concentration and the amount collected.
["This test measures hippurate and creatinine in a 24-hour urine collection to help evaluate urinary excretion and interpret the hippurate result."]
Key facts at a glance
- LOINC
- 44370-5
- Short code
- Hippurate/Creat 24h Ur
- Synonyms
- Hippurate/Creat 24h Ur
- Category
- kidney
- Sample
- urine
- Container
- Sterile urine container
- Units
- N/A
- Ref low
- 3.5
- Ref high
- 7.2
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 10 mL
- Stability
- Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What is this test?
This test measures hippurate, also called hippuric acid, and creatinine in all urine collected over a 24-hour period. Hippurate can be affected by certain chemical exposures, while creatinine provides information about urine concentration and the completeness of the collection.
Why might I need this test?
A clinician may order this test when evaluating exposure to benzene or related chemicals, or when interpreting another test affected by how concentrated the urine is. It may also be used as part of an assessment of how the body handles and eliminates certain substances.
How is the test performed?
Urine is collected into a designated container for 24 hours, including every urination during that period. The total volume is recorded, and a laboratory measures the hippurate and creatinine concentrations. The results may be reported for the full collection or as a hippurate-to-creatinine-adjusted value.
How do I prepare for the test?
Follow the collection instructions provided by the laboratory, and do not change your diet or stop medicines unless your clinician tells you to. Inform the care team about medicines, supplements, and possible chemical exposures. Keep the container closed and refrigerated if instructed, and return the complete collection within the specified time.
Reference range
NCBI: Uric Acid Male 3.5-7.2 mg/dL; Female 2.5-6.8 mg/dLN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Increased urinary hippurate can occur after exposure to benzene or certain other aromatic chemicals, but diet, medicines, and other factors may also affect it. The creatinine measurement and total urine volume help interpret the hippurate result and the adequacy of the collection. An abnormal result should be interpreted by a clinician in the context of exposure history, medications, kidney function, and collection quality.
Short name
24-Hour Urine Hippurate and Creatinine
Frequently asked questions
What does hippurate measure?
Why is creatinine measured with hippurate?
How is a 24-hour urine collection completed?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy