Hippurate/Creatinine [Mass Ratio], Urine
A urine test that compares hippurate with creatinine, helping account for differences in urine concentration.
["The ratio can help evaluate hippurate excretion when urine concentration or exposure history may affect the result."]
Key facts at a glance
- LOINC
- 110525-3
- Short code
- Hippurate/Creat Msmt Ur
- Synonyms
- Hippurate/Creat Msmt Ur
- Category
- kidney
- Sample
- urine
- Container
- Sterile urine container
- Units
- N/A
- Ref low
- 3.5
- Ref high
- 7.2
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 10 mL
- Stability
- Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What is this test?
This test measures hippurate, a substance formed when the body combines glycine with benzoic acid, and creatinine, a waste product used as a marker of urine concentration. The results are expressed as a hippurate-to-creatinine ratio.
Why might I need this test?
The test may be used to evaluate hippurate excretion in people being assessed for exposure to certain chemicals, such as toluene or xylene, or as part of an evaluation of unusual urine metabolites. It may also be included in broader metabolic testing.
How is the test performed?
A urine sample is analyzed in the laboratory for hippurate and creatinine. The laboratory compares the amounts of the two substances to calculate a ratio, which can help reduce the effect of variations in urine concentration.
How do I prepare for the test?
Follow any instructions provided by your healthcare professional. These may include collecting urine in a clean-catch container at a specific time or avoiding certain medications or chemical exposures. Tell the care team about occupational or household chemical exposure and provide complete collection instructions with the sample.
Reference range
NCBI: Uric Acid Male 3.5-7.2 mg/dL; Female 2.5-6.8 mg/dLN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Urinary hippurate-to-creatinine ratio
Frequently asked questions
What does hippurate measure?
Why is creatinine included in the test?
Does an abnormal result confirm chemical poisoning?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy