Skip to content

: HIST1H2B Gene Mutation Analysis, Tumor Tissue

Published: August 9, 2026Updated: August 16, 2026

: This test examines tumor tissue for mutations in a histone gene, which can help characterize certain cancers. It is typically ordered by a specialist as part of cancer evaluation.

Quick summary

[": This test looks for a specific gene mutation in tumor tissue to help classify and understand a cancer."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
104062-5
Short code
HISGT Histone genes Mut Anl Tumor
Synonyms
HISGT Histone genes Mut Anl Tumor
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

: What This Test Measures

: The test analyzes DNA from a tumor sample to look for changes, called mutations, in a histone gene. Histones are proteins that help package DNA, and alterations in their genes have been linked to particular types of tumors.

: How the Sample Is Collected

: A sample of tumor tissue is needed. This usually comes from a biopsy or a surgical procedure already being done for diagnosis. The tissue is sent to a laboratory where the gene is examined.

: What Results Can Mean

: A result may show that a mutation is present or not detected. A detected mutation can support a specific diagnosis or help your care team understand the tumor's characteristics. A negative result does not rule out cancer.

: Why Your Doctor May Order It

: Your doctor may order this test when the tumor's appearance suggests a cancer type associated with histone gene changes. Results are interpreted together with imaging, pathology, and other tests.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

: Histone gene mutations, particularly in genes such as HIST1H2B family members, have been described in certain bone and soft tissue tumors. Identifying such a mutation can aid in diagnosis and classification. This test is not a screening test for the general public, and results should always be interpreted by a qualified specialist in the context of the full clinical picture.

Short name

: Histone Gene Mutation Testing

Frequently asked questions

: Is this a routine blood test?
: No. This test requires tumor tissue, not blood, and is ordered for specific cancer evaluations rather than routine screening.
: Does a detected mutation mean the cancer is inherited?
: Not necessarily. Mutations found in tumor tissue are often acquired during a person's lifetime rather than inherited, but a genetics professional can clarify whether family testing is relevant.
: Can I get this test without a biopsy?
: No. The test needs a tissue sample, so it depends on whether a biopsy or surgical specimen is available. Discuss options with your care team.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy