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Histamine and Creatinine, Urine — Creatinine-Adjusted Ratio

Published: August 9, 2026Updated: August 16, 2026

This urine test measures histamine and compares it with creatinine from the same sample, helping evaluate histamine excretion when urine collection may be incomplete.

Quick summary

["An elevated histamine-to-creatinine ratio may indicate increased histamine release, but symptoms and other tests are needed for diagnosis."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
44371-3
Short code
Histamine/Creat Ur-sRto
Synonyms
Histamine/Creat Ur-sRto
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures histamine in urine and compares it with creatinine measured in the same sample. Creatinine adjustment can help account for variations in urine concentration or an incomplete urine collection.

Why might I need this test?

A clinician may order this test when symptoms suggest excessive histamine release, such as flushing, hives, abdominal discomfort, diarrhea, wheezing, or episodes of low blood pressure. It may also be used when evaluating certain conditions involving mast cells or histamine metabolism.

How is the test performed?

A urine specimen is collected and analyzed for histamine and creatinine. The results may be reported as a histamine-to-creatinine ratio, which helps show how much histamine is present relative to the amount of urine collected.

How do I prepare for the test?

Follow the collection instructions provided by your clinician, including any timing or repeat-collection requirements. Your clinician may advise avoiding certain foods or medicines that can affect histamine, but do not stop prescribed medicines without medical guidance.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urine histamine-to-creatinine ratio

Frequently asked questions

Is this the same as a 24-hour urine test?
Not necessarily. The required collection method depends on the laboratory order, and some histamine results are obtained from a complete 24-hour collection rather than a single specimen.
Why is creatinine included in the result?
Creatinine is used to adjust the histamine value for urine concentration and collection amount. This can make the result more useful than an unadjusted urine histamine measurement.
Do foods or medicines affect this test?
Yes. Histamine-rich foods, alcohol, and certain medicines may alter results. Ask your clinician whether any restrictions or medication adjustments are appropriate before the collection.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy