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Histone Antibody Screening Test (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures antibodies against histone proteins, which may help identify certain autoimmune conditions affecting connective tissues.

Quick summary

["Autoimmune antibodies linked to inflammation or tissue damage can be detected with this simple blood test."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
8071-3
Short code
Histone Ab Ser Ql
Synonyms
Histone Ab Ser Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is This Test For?

Histones are proteins found in cells that help package DNA. When the immune system mistakenly attacks these proteins, it may signal an autoimmune disorder, such as systemic lupus erythematosus (SLE) or other connective tissue diseases. This test screens for the presence of such antibodies in your blood.

Why Might Your Doctor Order This Test?

Your doctor may recommend this test if you have symptoms like joint pain, fatigue, rash, or other signs of an autoimmune condition. It can also be part of a broader evaluation when other tests suggest inflammation or immune system involvement.

What Does a Positive Result Mean?

A positive result means antibodies against histones were detected. This finding is often associated with certain types of lupus or other autoimmune diseases, but it does not confirm a diagnosis alone. Further testing and clinical correlation are needed to determine the cause of your symptoms.

How Is This Test Performed?

A small blood sample is drawn from your arm. The serum or plasma is then tested for histone antibodies using an immunoassay method, which detects the presence of these antibodies in your blood.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Histone Antibody Screen

Frequently asked questions

What are the most common symptoms that might lead to this test?
Symptoms like persistent fatigue, joint pain, rashes, fever, or unexplained weight changes may prompt your doctor to order this test, especially if other tests suggest an autoimmune cause.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on lab processing times. Your doctor will discuss the findings with you during your follow-up visit.
Can lifestyle changes affect this test result?
While lifestyle factors like diet or stress may influence overall health, they do not directly alter the presence of histone antibodies in this test. However, managing symptoms of autoimmune conditions often requires medical treatment and lifestyle adjustments.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy