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Histone Antibody Screening Test (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures antibodies against histone proteins, which are involved in packaging DNA in cells. It helps detect certain autoimmune conditions, including systemic lupus erythematosus (SLE) and other connective tissue disorders.

Quick summary

["This screening helps identify potential autoimmune diseases by detecting unusual antibodies linked to inflammation and tissue damage."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
5217-5
Short code
Histone Ab Ser Ql IF
Synonyms
Histone Ab Ser Ql IF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Doctors may order this test if you have symptoms like joint pain, fatigue, rash, or unexplained fever. It can also be used as part of a broader evaluation for autoimmune diseases, especially when other tests are inconclusive or when symptoms suggest conditions like lupus.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, either from a vein (venipuncture) or through finger pricking, depending on the lab procedure. Avoid strenuous activity or excessive alcohol 24 hours before testing.

What the Test Results Mean

Positive results suggest the presence of histone antibodies, which may indicate an autoimmune condition. However, further testing and evaluation by a healthcare provider are needed to confirm a diagnosis and guide treatment.

Common Conditions Linked to Positive Results

Histone antibodies are often associated with systemic lupus erythematosus (SLE) or other autoimmune disorders affecting connective tissues. They may also appear in conditions like anti-phospholipid syndrome or certain drug-induced lupus.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Histone Antibody Screen

Frequently asked questions

What does a positive result mean for my health?
A positive result indicates the presence of histone antibodies, which may raise suspicion for autoimmune conditions like lupus. Your doctor will review these results with your full medical history and other tests to assess risks and guide further evaluation.
Can this test be used to diagnose lupus?
No, this test alone cannot diagnose lupus. It is a screening tool. Doctors use multiple tests, symptoms, and clinical judgment to diagnose autoimmune diseases like lupus. Repeat testing or additional evaluations may be needed.
How often should I get this test if I have a history of autoimmune diseases?
Your doctor will determine the frequency based on your symptoms, disease activity, and other test results. Regular monitoring may be recommended, but it depends on your individual care plan and ongoing health needs.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy