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Histone H2A (H2AB) Antibody, Serum/Plasma (Quantitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of antibodies directed against a specific histone protein (H2A) found in cell nuclei. Histones are key components of chromatin and play a role in DNA packaging. Antibodies against histones can be linked to certain autoimmune conditions.

Quick summary

["This test helps identify autoimmune disorders involving histone proteins, which may affect how your immune system responds to your body’s own cells."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
18230-3
Short code
Histone H2a+H2b Ab Ser-aCnc
Synonyms
Histone H2a+H2b Ab Ser-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may order this test if you have symptoms or a history suggestive of autoimmune diseases, such as systemic lupus erythematosus (SLE) or other connective tissue disorders. It may also be used to monitor disease activity or response to treatment in certain cases.

What to Expect Before the Test

No special preparation is typically needed. You may have a blood sample drawn from a vein in your arm. If you’re on blood thinners or have a history of bleeding disorders, let your doctor know before the test.

What the Test Results Mean

Results are usually reported as a concentration level of antibodies in your serum or plasma. Elevated levels may indicate an autoimmune response targeting histone proteins, but interpretation depends on clinical context, including your symptoms and other test results.

Common Conditions Linked to Positive Results

Positive results for histone H2A antibodies are often associated with systemic lupus erythematosus (SLE) or other autoimmune conditions affecting connective tissues. However, they can also appear in other inflammatory or autoimmune diseases.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Anti-Histone H2A Antibody

Frequently asked questions

What does a positive result mean for my health?
A positive result for histone H2A antibodies may indicate an autoimmune response, often linked to conditions like SLE. However, it doesn’t diagnose the disease alone. Your doctor will review your symptoms, other test results, and medical history to guide next steps, which may include additional testing or monitoring.
Can this test be used to monitor my disease progression?
In some cases, yes. If you have a known autoimmune condition, repeated testing may help track changes in antibody levels over time. Your healthcare provider will determine if monitoring is appropriate based on your specific situation.
Are there any risks or side effects from this blood test?
The most common side effect is mild discomfort or bruising at the needle insertion site. Rarely, there may be a slight reaction like swelling or redness. If you experience excessive bleeding, severe pain, or signs of infection (like fever or increased pain), contact your doctor immediately.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy