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Histone H2A (H2A.B) Antibody Screening Test (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test detects antibodies against a specific protein found in cell nuclei, which may be linked to certain autoimmune conditions or inflammatory responses.

Quick summary

["This screening helps identify potential autoimmune or inflammatory conditions by checking for unusual immune responses to nuclear proteins."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
16969-8
Short code
Histone H2a+H2b Ab Ser IF-aCnc
Synonyms
Histone H2a+H2b Ab Ser IF-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test measures the presence of antibodies directed against histone H2A, a core protein in chromatin. Histones are essential for packaging DNA in cells. Elevated or abnormal levels of these antibodies may suggest an autoimmune reaction or other systemic conditions.

Why It Might Be Ordered

Your healthcare provider may order this test if you have symptoms suggestive of autoimmune diseases (e.g., joint pain, fatigue, rash), if you’ve been diagnosed with a condition involving nuclear proteins, or if you’re undergoing evaluation for unexplained inflammation.

Sample Collection and Preparation

Blood is drawn from a vein, typically in your arm. The sample is processed into either serum (after clotting) or plasma (using an anticoagulant). This test uses serum or plasma for analysis.

What to Expect Before the Test

No special preparation is usually needed, but inform your provider about any medications, recent infections, or conditions that might affect results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

H2A Antibody Screen

Frequently asked questions

This test is primarily a screening tool. Positive results may warrant further testing, such as confirmation assays, to determine the specific type of autoimmune response or underlying cause. It is not a definitive diagnosis but can guide further medical evaluation.
Positive results may indicate an autoimmune response targeting nuclear proteins, potentially linked to conditions like systemic lupus erythematosus (SLE) or other connective tissue diseases. Follow-up testing and clinical correlation are essential.
FAQ 1: What does a positive result mean?
A positive result suggests the presence of antibodies against histone H2A, which may signal an immune response. This does not diagnose a specific condition but may prompt further evaluation to explore possible autoimmune or inflammatory processes.
FAQ 2: Can lifestyle changes affect this test?
While some autoimmune conditions may be influenced by lifestyle factors, this specific test measures antibodies and is not directly affected by diet, exercise, or stress unless they directly impact immune function. Always follow your provider’s guidance.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy