Histone H2A (H2A.B) Antibody, Serum
This test measures antibodies against a specific protein found in cell nuclei, often linked to certain autoimmune conditions.
["This test helps diagnose or monitor autoimmune diseases involving nuclear proteins."]
Key facts at a glance
- LOINC
- 31424-5
- Short code
- Histone H2a+H2b Ab Ser Ql
- Synonyms
- Histone H2a+H2b Ab Ser Ql
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may recommend this test if you have symptoms or conditions associated with autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis, or other connective tissue disorders. It may also be used to assess response to treatment or monitor disease activity.
What to Expect Before the Test
No special preparation is typically required. You may fast or avoid certain medications for a few hours before the test, but always follow your provider’s instructions. Bring a list of medications you’re currently taking.
How the Test Works
A blood sample is drawn from a vein in your arm. The blood is processed to separate serum, which is then tested for the presence of antibodies against histone H2A. The method used is likely an immunoassay, which detects the antibodies in your serum.
What the Results Mean
Results are qualitative (positive or negative) and indicate whether your body has produced antibodies against histone H2A. Elevated levels may suggest an autoimmune response, but interpretation depends on clinical context and other test results.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Histone Antibody Test
Frequently asked questions
This test is primarily used to support a diagnosis of autoimmune diseases involving nuclear antigens, such as systemic lupus erythematosus (SLE). Positive results can help confirm the presence of these conditions or guide treatment decisions.
What does a positive result mean for my health?
Can I take anything to lower my antibody levels before the test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy