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Histone IgG Immunoglobulin (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures antibodies to histone proteins, which may help identify certain autoimmune conditions affecting joints, skin, or blood vessels.

Quick summary

["This test helps diagnose or monitor autoimmune diseases linked to histone antibodies."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
109975-3
Short code
Histone IgG Msmt Ser
Synonyms
Histone IgG Msmt Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like joint pain, rash, or blood vessel issues that could suggest autoimmune disorders such as systemic lupus erythematosus (SLE) or other connective tissue diseases. Histone antibodies are sometimes linked to these conditions, though not always.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from a vein in your arm. The test is quick and typically done in a lab setting.

How the Test Works

Blood is drawn and tested for antibodies that bind to histone proteins. The test detects the presence and level of these antibodies using an immunoassay method.

Results and Interpretation

Results are qualitative (positive or negative) and indicate whether histone antibodies are present. Elevated levels may suggest an autoimmune condition, but further testing and clinical correlation are needed for diagnosis.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Positive results for histone antibodies can be associated with autoimmune diseases like SLE or other connective tissue disorders. However, not all patients with these diseases test positive, and other tests may be needed to confirm a diagnosis. This test is often used as part of a broader evaluation for suspected autoimmune conditions.

Short name

Histone Antibodies (Serum)

Frequently asked questions

What does a positive result mean?
A positive result means your blood contains antibodies to histone proteins, which may indicate an autoimmune condition like SLE or another connective tissue disorder. Your doctor will discuss next steps, such as additional testing or monitoring, based on your symptoms and overall health.
Can this test be used to diagnose lupus?
This test alone is not definitive for lupus. Histone antibodies are more commonly linked to a specific subtype of lupus (lupus erythematosus profundus) or other autoimmune diseases. Doctors often use this test in combination with other clinical findings, symptoms, and tests to diagnose conditions like lupus.
How often should I get this test?
Your doctor will determine how often you need this test based on your symptoms, medical history, and treatment plan. Some patients may need it periodically to monitor their condition, while others may only need it once for initial evaluation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy