Histone IgG Antibody Screening Test (Serum)
This test measures antibodies against histone proteins, which may be linked to certain autoimmune conditions. Histones are proteins found in cells that help package DNA.
["This screening helps identify potential autoimmune responses that could affect connective tissues or joints."]
Key facts at a glance
- LOINC
- 31423-7
- Short code
- Histone IgG Ser-aCnc
- Synonyms
- Histone IgG Ser-aCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82784
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Does This Test Measure?
The test detects the presence of antibodies (IgG class) that target histone proteins, which are components of chromatin (the complex of DNA and proteins in cells). These antibodies may appear in conditions like systemic lupus erythematosus (SLE) or other autoimmune disorders.
Why Might You Need This Test?
Your healthcare provider may order this test if you have symptoms like joint pain, rash, fatigue, or other signs of an autoimmune condition. It can also be part of a broader evaluation for unexplained inflammatory or connective tissue diseases.
What to Expect Before the Test
No special preparation is usually needed. You may fast for 8–12 hours before the test if instructed, but confirm with your provider. Bring any medications you’re taking, as some may affect results.
What Happens During the Test?
A small blood sample is drawn from a vein in your arm. The blood is processed to separate serum (the liquid part) for testing. The lab analyzes the serum for histone-specific antibodies using an immunoassay method.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Histone Autoantibody Screen
Frequently asked questions
This test helps diagnose or monitor autoimmune diseases like systemic lupus erythematosus (SLE) or other connective tissue disorders. Positive results suggest an immune response targeting histone proteins, which may indicate inflammation or tissue damage.
A positive result means your blood contains antibodies against histone proteins. This may support a diagnosis of an autoimmune condition, but further testing (like a confirmatory assay) and clinical correlation are needed to determine the exact cause of your symptoms.
While some autoimmune conditions may be influenced by diet, stress, or other factors, this test itself does not require lifestyle adjustments. Focus on following your doctor’s recommendations for managing symptoms or monitoring your condition.
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy