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Histopathological Examination of Colon Endoscopic Specimen

Published: August 9, 2026Updated: August 16, 2026

This test examines tissue samples taken from your colon during an endoscopy to check for abnormalities like inflammation, polyps, or cancer.

Quick summary

["A biopsy helps doctors diagnose potential health issues in your digestive tract."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
111959-3
Short code
Histopath dx Colon Endscpy
Synonyms
Histopath dx Colon Endscpy
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
endoscopy
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is a Colon Biopsy?

A colon biopsy involves removing small tissue samples from your colon during an endoscopy. These samples are then sent to a lab for microscopic examination by a pathologist to identify any abnormal cells or conditions, such as inflammation, infection, or precancerous changes.

How Is the Biopsy Performed?

During an endoscopy, a flexible tube with a light and camera (endoscope) is inserted into your rectum and advanced through your colon. If needed, small tissue samples are taken using specialized tools. You may feel mild discomfort, but it’s usually quick and well-tolerated with sedation if required.

What Does the Test Involve After Removal?

After removal, the tissue samples are processed, stained, and examined under a microscope by a pathologist. The results determine whether normal tissue, inflammation, polyps, or other abnormalities are present, guiding further medical decisions.

When Might You Need This Test?

You may need a colon biopsy if you have symptoms like unexplained weight loss, persistent abdominal pain, changes in bowel habits, or if screening tests (like a colonoscopy) find suspicious areas.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Colon Biopsy Pathology

Frequently asked questions

Why do I need a colon biopsy if my colonoscopy was normal?
Even if your colonoscopy appears normal, a biopsy may be recommended if your doctor suspects subtle abnormalities, such as microscopic inflammation or early signs of disease that aren’t visible during the procedure.
What are the possible risks or side effects of a colon biopsy?
Common side effects may include mild discomfort, slight bleeding, or minor irritation at the biopsy site. Severe complications are rare but can include infection or perforation of the colon. Your doctor will discuss risks before the procedure.
How long will it take to get my biopsy results?
Results typically take 1–3 business days, depending on the complexity of the sample and the pathologist’s workload. Your doctor will contact you once the results are ready.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy