Histopathological examination of bone biopsy for diagnosis of bends (osteonecrosis)
This test involves examining a small sample of bone tissue taken from your body to check for signs of bone damage or disease, such as avascular necrosis (commonly called 'the bends'). It helps doctors diagnose conditions affecting bone health and circulation.
["A bone biopsy may be needed to confirm or investigate suspected bone problems like avascular necrosis."]
Key facts at a glance
- LOINC
- 111965-0
- Short code
- Histopath dx SB Endscpy
- Synonyms
- Histopath dx SB Endscpy
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- endoscopy
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why is this test done?
Your healthcare provider may recommend this test if you have symptoms like joint pain, swelling, or limited movement in your hips, knees, or other joints. It could also be suggested if you’ve had a history of conditions that increase your risk of bone damage, such as long-term steroid use, trauma, or certain blood disorders.
What happens during the test?
A small piece of bone is taken from your body, usually from the hip or knee, under local anesthesia. The sample is then sent to a lab for microscopic examination by a pathologist to look for signs of tissue damage, cell changes, or other abnormalities related to conditions like avascular necrosis.
What does the test involve after collection?
The bone sample is processed and stained to highlight different tissue structures. A pathologist examines the tissue under a microscope to identify any abnormalities, such as dead or dying bone cells, inflammation, or other signs of disease. This detailed review helps determine if you have conditions like avascular necrosis or other bone-related issues.
What does the test result mean?
The result will describe the condition of your bone tissue, such as whether there are signs of avascular necrosis, infection, or other bone diseases. Your doctor will use these findings alongside your symptoms and medical history to guide treatment decisions.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical significance: This test is critical for diagnosing avascular necrosis (also called osteonecrosis) and other bone diseases. Early detection can help prevent further damage and guide appropriate treatment, such as lifestyle changes, medications, or surgical interventions.
Short name
Bone biopsy pathology review
Frequently asked questions
What is avascular necrosis?
How can I prepare for this test?
Will the biopsy hurt?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy