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Histopathological examination of bone biopsy for diagnosis of bends (osteonecrosis)

Published: August 9, 2026Updated: August 16, 2026

This test involves examining a small sample of bone tissue taken from your body to check for signs of bone damage or disease, such as avascular necrosis (commonly called 'the bends'). It helps doctors diagnose conditions affecting bone health and circulation.

Quick summary

["A bone biopsy may be needed to confirm or investigate suspected bone problems like avascular necrosis."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
111965-0
Short code
Histopath dx SB Endscpy
Synonyms
Histopath dx SB Endscpy
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
endoscopy
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why is this test done?

Your healthcare provider may recommend this test if you have symptoms like joint pain, swelling, or limited movement in your hips, knees, or other joints. It could also be suggested if you’ve had a history of conditions that increase your risk of bone damage, such as long-term steroid use, trauma, or certain blood disorders.

What happens during the test?

A small piece of bone is taken from your body, usually from the hip or knee, under local anesthesia. The sample is then sent to a lab for microscopic examination by a pathologist to look for signs of tissue damage, cell changes, or other abnormalities related to conditions like avascular necrosis.

What does the test involve after collection?

The bone sample is processed and stained to highlight different tissue structures. A pathologist examines the tissue under a microscope to identify any abnormalities, such as dead or dying bone cells, inflammation, or other signs of disease. This detailed review helps determine if you have conditions like avascular necrosis or other bone-related issues.

What does the test result mean?

The result will describe the condition of your bone tissue, such as whether there are signs of avascular necrosis, infection, or other bone diseases. Your doctor will use these findings alongside your symptoms and medical history to guide treatment decisions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical significance: This test is critical for diagnosing avascular necrosis (also called osteonecrosis) and other bone diseases. Early detection can help prevent further damage and guide appropriate treatment, such as lifestyle changes, medications, or surgical interventions.

Short name

Bone biopsy pathology review

Frequently asked questions

What is avascular necrosis?
Avascular necrosis is a condition where a bone loses blood supply, leading to cell death and potential collapse of the bone structure. It often affects joints like the hip or knee and can cause pain and disability if untreated.
How can I prepare for this test?
You may need to avoid certain medications or supplements that could affect healing, such as steroids, before the procedure. Follow your doctor’s instructions closely, and inform them about any allergies or health conditions you have.
Will the biopsy hurt?
You may feel some discomfort during the procedure, but local anesthesia will numb the area. Most people experience mild pain afterward, which can be managed with prescribed pain relievers. Recovery typically involves rest and avoiding heavy lifting for a few days.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy