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HIV Antibody Screening and Confirmation (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test detects antibodies to the human immunodeficiency virus (HIV) in your blood or plasma. It helps determine if you have been exposed to HIV.

Quick summary

["This test screens for HIV antibodies to check for past or current infection."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
22357-8
Short code
HIV1+2 Ab Ser-aCnc
Synonyms
HIV1+2 Ab Ser-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
86701
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test looks for antibodies produced by your immune system in response to HIV. These antibodies are created when your body encounters the virus. If antibodies are found, it suggests prior exposure to HIV, though they may not always indicate an active infection at the time of testing. This test is typically used as part of a screening process to identify potential HIV exposure.

How Is the Sample Collected?

A small amount of blood is drawn from a vein in your arm by a healthcare professional. The blood is then processed to separate the serum or plasma for testing. This process is quick and usually causes only minor discomfort.

Why Might You Need This Test?

You may need this test if you have risk factors for HIV, such as unprotected sexual contact, sharing needles, or other behaviors that increase exposure risk. It may also be recommended as part of routine health check-ups, especially if you are in a high-risk group. Early detection is crucial for managing HIV and preventing complications.

What Are the Next Steps?

If the screening test is positive, your healthcare provider will likely perform a confirmatory test to ensure accuracy. If the screening test is negative but you suspect exposure, additional testing may be advised. Always follow up with your healthcare provider for guidance based on your specific situation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Positive results indicate the presence of HIV antibodies, suggesting past or current infection. While antibodies can appear within weeks to months after exposure, they may not always be detectable immediately. Early detection is vital for initiating treatment, preventing disease progression, and supporting overall health. Negative results mean no detectable antibodies were found at the time of testing, but this does not definitively rule out HIV. Follow-up testing may be needed if there is ongoing risk of exposure.

Short name

HIV Antibody Test

Frequently asked questions

How soon can I expect results?
Results are typically available within a few days to a week, depending on the lab and testing process. Your healthcare provider will contact you with the results once they are ready.
What if my test is positive?
A positive screening result will be followed by a confirmatory test to confirm the diagnosis. If confirmed, you will receive guidance on next steps, which may include starting antiretroviral therapy (ART) to manage the virus and improve your health. Support services, such as counseling and connections to healthcare providers, may also be provided.
Can I still be infected if my test is negative?
Yes, a negative screening result means no detectable antibodies were found at the time of testing, but it does not guarantee you are not infected. HIV can sometimes take time to develop antibodies, or the infection may be very early. If you suspect exposure, discuss further testing with your healthcare provider, especially if you have ongoing risk factors.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy