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HIV-1 Antibody Screening by Immunoassay (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies to the human immunodeficiency virus (HIV), which your body makes in response to the virus. Antibodies can appear in your blood after infection, often within weeks to months.

Quick summary

["Detects early HIV infection through antibody presence in blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
106883-2
Short code
HIV1+2 T. pallidum Ab SPB IA
Synonyms
HIV1+2 T. pallidum Ab SPB IA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia-rapid
CPT
86701
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have risk factors for HIV, such as unprotected sex, shared needles, or exposure to HIV. It’s also part of routine testing for certain groups (e.g., pregnant women, people with sexually transmitted infections).

How the Test Works

A small blood sample is taken from your arm and sent to a lab. The test uses an immunoassay method to detect HIV antibodies in your serum or plasma. This method is highly sensitive and helps identify potential infection early.

What to Expect Before the Test

No special preparation is needed. You may have a slight bruise or discomfort at the injection site, but this usually fades quickly. Avoid alcohol before the test, as it may affect blood clotting.

What to Expect After the Test

You can return to your normal activities immediately. If you experience excessive bleeding or pain, contact your healthcare provider. Store your blood sample as instructed if you need to follow up for results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

HIV Antibody Screen

Frequently asked questions

A positive result means your body has detected HIV antibodies, indicating possible infection. Follow-up testing (like a confirmatory assay) is needed to confirm the diagnosis. A negative result means no detectable antibodies at this time, but HIV can still be present if you were recently exposed.
This test does not diagnose HIV immediately. If you’re at high risk, your provider may recommend additional testing (e.g., viral load or PCR) to check for active virus.
If you have a positive screening result, your healthcare provider will guide you on next steps, which may include confirmatory testing or referral to an HIV specialist.
Antibodies may take weeks to months to develop after exposure. If you’ve been exposed recently, your provider may recommend testing sooner or differently.
Does this test detect HIV at all stages of infection?
Yes, but early infections (like acute HIV) may not show antibodies yet. Some people test negative for weeks before antibodies appear. Follow-up testing is key for accurate results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy