Skip to content

HIV-1 Antibody Screening Test (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test detects antibodies to the human immunodeficiency virus (HIV), which your body produces in response to the virus. It helps determine if you may have been exposed to HIV.

Quick summary

["This screening test is the first step in checking for HIV infection."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
35439-9
Short code
HIV1 Ab Sal Ql IB
Synonyms
HIV1 Ab Sal Ql IB
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ib
CPT
86701
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Healthcare providers use this test to screen for HIV, especially in people who may be at higher risk of infection. It can also be part of routine testing for certain groups, such as sexually active adults, people with multiple sexual partners, or those with known exposure to HIV.

What to Expect Before the Test

No special preparation is needed. You may have a blood draw from a vein in your arm, or sometimes a small amount of blood may be collected from your finger. The process usually takes a few minutes.

How the Test Works

The test uses an immunoassay method to detect HIV antibodies in your blood or plasma. If HIV antibodies are present, they bind to virus particles or probes in the test, triggering a reaction that can be measured and identified.

What the Results Mean

A positive result means your blood contains antibodies to HIV, suggesting you may have been infected. A negative result means no antibodies were detected, but it does not guarantee you are not infected. Follow-up testing may be needed for confirmation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

HIV Antibody Screen

Frequently asked questions

Early detection of HIV is crucial for managing the infection and preventing complications. This test helps identify potential infections quickly, allowing for timely medical intervention, treatment, and support.
A positive result should be confirmed with additional testing (such as a confirmatory HIV antibody test or viral load test) to ensure accuracy. If you have symptoms of HIV or risk factors, discuss your results with your healthcare provider.
What does a positive result mean for my health?
A positive result indicates you may have HIV, but it does not confirm the diagnosis immediately. Your healthcare provider will perform additional tests to confirm the infection and guide you on the next steps, including treatment options and support.
Can I still get HIV if I have a negative test result?
Yes, HIV testing is not 100% accurate on the first test. If you have risk factors for HIV, repeat testing is recommended. If you have symptoms or suspect exposure, consult your healthcare provider for further evaluation.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy