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HIV Antibody Screening Test (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test detects antibodies to the human immunodeficiency virus (HIV), which your body produces in response to infection. It helps determine if you have been exposed to HIV.

Quick summary

["This screening test is the first step in checking for HIV infection."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
21007-0
Short code
HIV1 Ab Ser Donr Ql
Synonyms
HIV1 Ab Ser Donr Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
86701
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test looks for HIV antibodies in your blood or plasma. These antibodies are proteins your immune system makes after exposure to HIV. If present, they indicate past or current infection. This test is designed to be highly sensitive and is the standard first step in HIV testing.

How the Test Works

Your sample is analyzed using an immunoassay method, which detects the presence of HIV antibodies. The test is qualitative, meaning it provides a yes/no result rather than a specific quantity.

Why It’s Done

HIV antibody screening is recommended for everyone at least once as part of routine health checks, especially if you are at higher risk for HIV (e.g., unprotected sex, shared needles, or living with someone who has HIV). It can also be done if you have symptoms of HIV or have been exposed to the virus.

What to Expect Before the Test

No special preparation is needed. You may have a blood draw, where a small amount of blood is taken from your arm. If you are tested with a urine sample, you may be asked to collect a midstream urine sample. Always inform your healthcare provider about any medications or conditions that could affect your test results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test plays a critical role in early detection of HIV. Early diagnosis allows for prompt treatment, which can help manage the virus and improve long-term health outcomes. It is also important for preventing HIV transmission to others. If your test result is positive, further confirmatory testing will be done to confirm the diagnosis.

Short name

HIV Antibody Screen

Frequently asked questions

What does a positive result mean?
A positive result means your test detected HIV antibodies, suggesting you may have been infected. However, it is not definitive. You will need additional confirmatory tests to confirm the diagnosis. Follow-up testing is essential to ensure accurate results and guide next steps in care.
What if my test result is negative?
A negative result means your test did not detect HIV antibodies at the time of testing. This does not guarantee you are not infected, as it may take weeks or months for your body to produce detectable antibodies after exposure. Consider getting tested again if you have been exposed to HIV or have symptoms.
How often should I get tested?
The CDC recommends HIV testing at least once as part of routine health screenings. If you are at higher risk, you may need to be tested more frequently, such as every 3 to 12 months. Always discuss your risk factors and testing schedule with your healthcare provider.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy