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HIV Antibody Screening Test (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test detects antibodies to the human immunodeficiency virus (HIV), which your body produces in response to infection. It helps determine if you may have been exposed to HIV.

Quick summary

["This screening test is the first step in checking for HIV infection."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
5221-7
Short code
HIV1 Ab SerPl Ql IB
Synonyms
HIV1 Ab SerPl Ql IB
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ib
CPT
86701
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test looks for HIV antibodies in your blood or plasma. Antibodies are proteins your immune system makes to fight off infections. If you’ve been exposed to HIV, your body may produce these antibodies within weeks to months after exposure.

How the Test Works

Your sample is tested using an immunoassay method, which detects specific antibodies against HIV. This is typically done through a lab process that identifies the presence of these antibodies without measuring their exact quantity.

Why It’s Done

Doctors often recommend this test if you have risk factors for HIV, such as unprotected sex, shared needles, or other behaviors that increase exposure risk. It may also be part of routine testing for certain groups, like sexually active adults or those with sexually transmitted infections.

What to Expect Before the Test

No special preparation is needed. You may have a blood draw from a vein in your arm, or a small sample of blood may be collected from your finger. If you’re using blood thinners, let your provider know before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test is used as a screening tool to identify potential HIV infection. A positive result means further testing (like a confirmatory HIV antibody test) is needed to confirm the diagnosis. A negative result means you likely do not have HIV at the time of testing, but you should still practice safe behaviors and get tested again if you have risk factors.

Short name

HIV Antibody Screen

Frequently asked questions

What does a positive result mean?
A positive result on this screening test means your body may have produced HIV antibodies, suggesting past or recent exposure. You’ll need additional testing to confirm if you have HIV.
How soon can I get results?
Results are usually available within a few days to a week, depending on your lab. Follow-up instructions from your healthcare provider will guide next steps.
Can I get false positives?
While rare, false positives can occur, especially in early infection stages or with certain medical conditions. If your screening test is positive, confirmatory testing will help clarify the result.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy