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HIV-1, HCV, HBV Serology Panel with RNA Detection (Donor Sample)

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies and genetic material from three viruses—HIV-1, hepatitis C virus (HCV), and hepatitis B virus (HBV)—to help determine if you’ve been exposed or infected.

Quick summary

["Early detection helps manage infections and prevents long-term health risks."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
88453-6
Short code
HIV1+HCV+HBV SerPlBld Donr NAA+prb
Synonyms
HIV1+HCV+HBV SerPlBld Donr NAA+prb
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
CPT
86701
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test includes antibody screening for HIV-1, HCV, and HBV, followed by confirmatory testing for HCV and HBV RNA (genetic material) if antibodies are detected. This helps confirm active infection and rule out past exposure.

Why It Matters for Your Health

Detecting these viruses early allows for timely treatment, prevention of transmission, and management of chronic conditions like liver disease or immune suppression.

How the Test Works

Blood drawn from you is tested for antibodies (proteins the immune system makes in response to infection) and viral RNA (genetic material). If antibodies are found, additional testing confirms the presence of active viral RNA.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm, and you’ll rest briefly afterward. If you’re pregnant, breastfeeding, or have a bleeding disorder, let your provider know.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Viral Panel with RNA Testing

Frequently asked questions

Why might my provider order this test?
Your provider may recommend this test if you have risk factors for these infections (e.g., unprotected sex, shared needles, or exposure to infected blood), symptoms like fatigue, jaundice, or unexplained sores, or if you’re planning a pregnancy.
What does a positive result mean?
A positive result means you may have been infected with one or more of these viruses. Follow-up testing and medical evaluation will guide next steps, including treatment options.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on lab processing times. Your provider will discuss the findings with you during a follow-up visit.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy