HIV-1 Integrase Resistance Gene Mutation Detection (Serum/Plasma)
This test checks for specific genetic mutations in the integrase protein of HIV-1, which can affect how well certain antiviral medications work. It helps doctors tailor treatment to improve your response to therapy.
["This test helps personalize HIV treatment by identifying mutations that may reduce the effectiveness of specific drugs."]
Key facts at a glance
- LOINC
- 61199-6
- Short code
- HIV1 integrase gene Mut Det Islt
- Synonyms
- HIV1 integrase gene Mut Det Islt
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 86701
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Your doctor may recommend this test if you’re taking or considering antiretroviral therapy (ART) that targets HIV’s integrase enzyme. It helps ensure the medications you’re using are likely to work effectively against your virus, reducing the risk of treatment failure or drug resistance.
How the Test Works
A small sample of your blood (serum or plasma) is collected and analyzed for specific DNA sequences in the HIV integrase gene. Advanced laboratory techniques detect any mutations that may alter how the virus interacts with integrase inhibitors, the class of drugs used in many modern HIV treatments.
What to Expect Before the Test
No special preparation is needed. You may have a simple blood draw, similar to other routine blood tests. If you’re pregnant, breastfeeding, or have a bleeding disorder, let your doctor know before the test.
What to Expect During the Test
The test involves drawing blood from a vein in your arm. You may feel a slight pinch, but it usually takes only a few minutes. The sample is then sent to a lab for genetic analysis.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
This test is critical for monitoring resistance to integrase strand transfer inhibitors (INSTIs), a key class of HIV medications. Certain mutations can make your virus less responsive to these drugs, requiring adjustments to your treatment plan. Early detection helps prevent treatment failure and ensures you stay on an effective regimen, improving your long-term health and quality of life.
Short name
HIV Integrase Mutation Test
Frequently asked questions
When would this test be recommended?
What does a positive result mean?
How often should this test be done?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy