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HIV-1 Subtype Detection by Nucleic Acid Amplification Probe (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test checks for specific types (subtypes) of the HIV-1 virus in your blood using a molecular method to help determine which subtype may be present if infection is confirmed by other tests.

Quick summary

["Helps healthcare providers tailor treatment and monitor response to antiretroviral therapy based on subtype identification."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
73658-7
Short code
HIV 1 subtype Spec NAA+probe
Synonyms
HIV 1 subtype Spec NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
CPT
86701
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if they suspect HIV-1 infection and want to identify the subtype of the virus. Subtype identification can influence treatment choices, especially in regions where certain subtypes are more common.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample (serum or plasma) via a simple venipuncture. The sample is processed in a lab to detect viral genetic material.

How the Test Works

The test uses a nucleic acid amplification probe to detect HIV-1 genetic sequences. This method is highly sensitive and specific, allowing for subtype classification based on viral genetic markers.

What the Results Mean

Results indicate the presence of a specific HIV-1 subtype if detected. A negative result means no subtype was identified in the sample. Results are critical for guiding treatment decisions, such as selecting medications effective against the subtype.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Identifying the HIV-1 subtype assists healthcare providers in selecting antiretroviral therapy (ART) that is most likely to be effective against the virus. Some subtypes may respond differently to certain drugs, and subtype information can also help monitor viral resistance over time.

Short name

HIV Subtype Test (NAAT)

Frequently asked questions

What does a positive result mean?
A positive result means the test detected genetic material from a specific subtype of HIV-1 in your blood. This subtype information helps your healthcare team choose the most appropriate treatment to target the virus effectively.
How long does it take to get results?
Results are typically available within 24 to 48 hours, depending on lab processing times. Your healthcare provider will contact you once results are ready.
Is this test covered by insurance?
Most insurance plans cover HIV testing and subtype detection as part of comprehensive HIV care. However, it’s best to confirm coverage with your insurance provider or ask your healthcare team for clarification.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy